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Comment on "A common genetic variant is associated with adult and childhood obesity".

Science (New York, N.Y.) - 12 Jan 2007

Dina Christian, Meyre David, Samson Chantal, Tichet Jean, Marre Michel, Jouret Beatrice, Charles Marie Aline, Balkau Beverley, Froguel Philippe

Abstract excerpt

Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and gener...

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Identifiers

PMID: 17218508
DOI: 10.1126/science.1129402

Genes

INSIG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17218508-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Comment on "A common genetic variant is associated with adult and childhood obesity".PMID 17218508Read ↗

Comment on "A common genetic variant is associated with adult and childhood obesity".Semantic proximity Read ↗

Comment on "A common genetic variant is associated with adult and childhood obesity".Semantic proximity Read ↗

A common genetic variant is associated with adult and childhood obesity.Semantic proximity Read ↗

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.Semantic proximity Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.Semantic proximity Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

A common polymorphism is associated with body mass index in Uyghur population.Semantic proximity Read ↗

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.Semantic proximity Read ↗

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.Semantic proximity Read ↗

Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

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