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Article

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.

Obesity (Silver Spring, Md.) - 1 Apr 2008

Boes Eva, Kollerits Barbara, Heid Iris M, Hunt Steven C, Pichler Michaela, Paulweber Bernhard, Coassin Stefan, Adams Ted D, Hopkins Paul N, Lingenhel Arno, Wagner Stefanie A, Kronenberg Florian

Abstract excerpt

OBJECTIVE: A previous epidemiological study showed an association of the insulin-induced gene 2 (INSIG2) gene with BMI. Additionally, experimental investigations in animals and cell culture provided evidence that this gene might be involved in lipoprotein and free fatty acid (FFA) metabolism. The...

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Source

Identifiers

PMID: 18239574
DOI: 10.1038/oby.2007.132

Genes

INSIG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18239574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.PMID 18239574Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

INSIG2 promoter variant, obesity markers and lipid parameters - No association in a large Slavonic Caucasian population sample.Semantic proximity Read ↗

No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.Semantic proximity Read ↗

Lack of association between a common polymorphism near the INSIG2 gene and BMI, myocardial infarction, and cardiovascular risk factors.Semantic proximity Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.Semantic proximity Read ↗

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).Semantic proximity Read ↗

INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.Semantic proximity Read ↗

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.Semantic proximity Read ↗

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.Semantic proximity Read ↗

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