Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).

doi:10.1038/oby.2008.650

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Article

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).

Obesity (Silver Spring, Md.) - 1 Jul 2009

Vimaleswaran Karani S, Franks Paul W, Brage Soren, Sardinha Luis B, Andersen Lars B, Wareham Nicholas J, Ekelund Ulf, Loos Ruth J F

Abstract excerpt

The first genome-wide association study for BMI identified a polymorphism, rs7566605, 10 kb upstream of the insulin-induced gene 2 (INSIG2) transcription start site, as the most significantly associated variant in children and adults. Subsequent studies, however, showed inconsistent association of this polymorphism with obesity traits. This polymorphism has been hypothesized to alter INSIG2 expression leading to...

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PMID: 19197262
DOI: 10.1038/oby.2008.650

Genes

INSIG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).PMID 19197262Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

Lack of association between a common polymorphism near the INSIG2 gene and BMI, myocardial infarction, and cardiovascular risk factors.Semantic proximity Read ↗

Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.Semantic proximity Read ↗

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.Semantic proximity Read ↗

INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.Semantic proximity Read ↗

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.Semantic proximity Read ↗

Comment on "A common genetic variant is associated with adult and childhood obesity".Semantic proximity Read ↗

No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.Semantic proximity Read ↗

Association of INSIG2 polymorphism with overweight and LDL in children.Semantic proximity Read ↗

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