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Article

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.

The American journal of clinical nutrition - 1 Jul 2010

Szopa Magdalena, Meirhaeghe Aline, Luan Jian'an, Moreno Luis A, Gonzalez-Gross Marcela, Vidal-Puig Antonio, Cooper Cyrus, Hagen Rachel, Amouyel Philippe, Wareham Nicholas J, Loos Ruth J F

Abstract excerpt

BACKGROUND: The insulin-induced gene 1 (INSIG1) encodes a protein that blocks proteolytic activation of sterol regulatory element binding proteins, which are transcription factors that activate genes that regulate cholesterol, fatty acid, and glucose metabolism. OBJECTIVE: We tested for associations between 6 INSIG1 tag single nucleotide polymorphisms (SNPs) (and captured all common variations in INSIG1) and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20444954
DOI: 10.3945/ajcn.2010.29422

Genes

INSIG1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.PMID 20444954Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.Semantic proximity Read ↗

Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.Semantic proximity Read ↗

Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China.Semantic proximity Read ↗

The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women.Semantic proximity Read ↗

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).Semantic proximity Read ↗

A common genetic variant is associated with adult and childhood obesity.Semantic proximity Read ↗

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.Semantic proximity Read ↗

INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.Semantic proximity Read ↗

Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children.Semantic proximity Read ↗

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.Semantic proximity Read ↗

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