INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.

doi:10.1186/1471-2350-7-83

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Article

INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.

BMC medical genetics - 30 Nov 2006

Hall Darroch H, Rahman Thahira, Avery Peter J, Keavney Bernard

Abstract excerpt

BACKGROUND: Obesity is a major public health problem. Body mass index (BMI) is a highly heritable phenotype but robust associations of genetic polymorphisms to BMI or other obesity-related phenotypes have been difficult to establish. Recently a large genetic association study showed evidence for association of the single nucleotide polymorphism (SNP) rs7566605, which lies 10 Kb 5' to the first exon of the...

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Identifiers

PMID: 17137505
DOI: 10.1186/1471-2350-7-83
PMCID: PMC1698479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.PMID 17137505Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.Semantic proximity Read ↗

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.Semantic proximity Read ↗

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).Semantic proximity Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.Semantic proximity Read ↗

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.Semantic proximity Read ↗

The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.Semantic proximity Read ↗

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.Semantic proximity Read ↗

No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.Semantic proximity Read ↗

Fine Mapping of a GWAS-Derived Obesity Candidate Region on Chromosome 16p11.2.Semantic proximity Read ↗

Comment on "A common genetic variant is associated with adult and childhood obesity".Semantic proximity Read ↗

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