Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk.

BMC medical genetics - 10 Jun 2009

Howarth Kimberley, Ranta Susanna, Winter Eitan, Teixeira Ana, Schaschl Helmut, Harvey John J, Rowan Andrew, Jones Angela, Spain Sarah, Clark Susan, Guenther Thomas, Stewart Aengus, Silver Andrew, Tomlinson Ian

Abstract excerpt

BACKGROUND: Mitotic recombination is important for inactivating tumour suppressor genes by copy-neutral loss of heterozygosity (LOH). Although meiotic recombination maps are plentiful, little is known about mitotic recombination. The APC gene (chr5q21) is mutated in most colorectal tumours and its usual mode of LOH is mitotic recombination. METHODS: We mapped mitotic recombination boundaries ("breakpoints")...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 5
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, APC

Share to Loss of Heterozygosity

Share to Microsatellite Repeats

Share to Mitosis

Share to Oligonucleotide Array Sequence Analysis

Share to Recombination, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 19515250
DOI: 10.1186/1471-2350-10-54
PMCID: PMC2705358

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk.PMID 19515250Read ↗

Mechanisms underlying losses of heterozygosity in human colorectal cancers.Semantic proximity Read ↗

Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression.Semantic proximity Read ↗

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.Semantic proximity Read ↗

Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer.Semantic proximity Read ↗

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers.Semantic proximity Read ↗

Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.Semantic proximity Read ↗

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks.Semantic proximity Read ↗

APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q1Semantic proximity Read ↗

Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis.Semantic proximity Read ↗

Mitotic crossover--an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma.Semantic proximity Read ↗

Whole genome amplification and high-throughput allelotyping identified five distinct deletion regions on chromosomes 5 and 6 in microdissected early-stage ovarian tumors.Semantic proximity Read ↗

Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice†.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.