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Article

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.

Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2002

Sieber O M, Heinimann K, Gorman P, Lamlum H, Crabtree M, Simpson C A, Davies D, Neale K, Hodgson S V, Roylance R R, Phillips R K S, Bodmer W F, Tomlinson I P M

Abstract excerpt

In vitro data show that the adenomatous polyposis coli (APC) protein associates with the mitotic spindle and that mouse embryonic stem cells with biallelic Apc mutations are karyotypically unstable. These findings led to suggestions that APC acts in chromosomal segregation and that APC inactivati...

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Source

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Identifiers

PMID: 12486240
DOI: 10.1073/pnas.012679099
PMCID: PMC139243

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12486240-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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