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Article

Mechanisms underlying losses of heterozygosity in human colorectal cancers.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2001

Thiagalingam S, Laken S, Willson J K, Markowitz S D, Kinzler K W, Vogelstein B, Lengauer C

Abstract excerpt

Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for losses of heterozygosity in such tumors. Here we report a detailed investigation of the five chromosomes lost most frequently in human colorectal cancers. A total of 10,216 determinations were made with 88 microsatellite...

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Source

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Identifiers

PMID: 11226302
DOI: 10.1073/pnas.051625398
PMCID: PMC30201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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