Article
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.
Cancer research - 1 Feb 2001
Shih I M, Zhou W, Goodman S N, Lengauer C, Kinzler K W, Vogelstein B
Abstract excerpt
Chromosomal instability is believed to be a common feature of most human tumors, but the stage at which such instability originates has not been defined. At the molecular level, chromosomal instability is characterized by allelic imbalance (AI), representing losses or gains of defined chromosomal regions. We have assessed AI in early colorectal tumors using newly developed methods for assessing AI in complex cell...
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