Article
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers.
Cancer research - 1 Apr 2006
Gaasenbeek Michelle, Howarth Kimberley, Rowan Andrew J, Gorman Patricia A, Jones Angela, Chaplin Tracy, Liu Ying, Bicknell David, Davison Eleanor J, Fiegler Heike, Carter Nigel P, Roylance Rebecca R, Tomlinson Ian P M
Abstract excerpt
Cancers with chromosomal instability (CIN) are held to be aneuploid/polyploid with multiple large-scale gains/deletions, but the processes underlying CIN are unclear and different types of CIN might exist. We investigated colorectal cancer cell lines using array-comparative genomic hybridization (CGH) for copy number changes and single-copy number polymorphism (SNP) microarrays for allelic loss (LOH). Many...
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