Article
A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse.
Neurogenetics - 1 May 2010
Lloyd Sarah E, Maytham Emma G, Grizenkova Julia, Hummerich Holger, Collinge John
Abstract excerpt
Prion disease incubation time in mice is determined by many factors including genetic background. The prion gene itself plays a major role in incubation time; however, other genes are also known to be important. Whilst quantitative trait loci (QTL) studies have identified multiple loci across the genome, these regions are often large, and with the exception of Hectd2 on Mmu19, no quantitative trait genes or...
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