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Article

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.

Molecular cell - 7 Nov 2008

Zeng Weizhong, Yuan Joseph P, Kim Min Seuk, Choi Young Jin, Huang Guo N, Worley Paul F, Muallem Shmuel

Abstract excerpt

The receptor-evoked Ca(2+) signal includes activation of the store-operated channels (SOCs) TRPCs and the Orais. Although both are gated by STIM1, it is not known how STIM1 gates the channels and whether STIM1 gates the TRPCs and Orais by the same mechanism. Here, we report the molecular mechanis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to ORAI1 Protein

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Share to Stromal Interaction Molecule 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 18995841
DOI: 10.1016/j.molcel.2008.09.020
PMCID: PMC2586614

Genes

STIM1
TRPC1
TRPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18995841-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.PMID 18995841Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Native Store-operated Ca2+ Influx Requires the Channel Function of Orai1 and TRPC1.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant.Semantic proximity Read ↗

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.Semantic proximity Read ↗

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits.Semantic proximity Read ↗

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels.Semantic proximity Read ↗

Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated stateSemantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

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