Upregulation of genes involved in gluconeogenesis and the glyoxylate cycle suppressed the drug sensitivity of an N-glycan-deficient Saccharomyces cerevisiae mutant.

Abstract excerpt

Saccharomyces cerevisiae strain TIY20, which produces a mammalian high-mannose type N-glycan, exhibits a severe growth defect due to disruption of yeast-specific outer chain mannosyltransferases. We have isolated a more fit strain, YAB103, from TIY20 by the use of a novel mutagenesis technique based on the disparity theory of evolution. To determine why YAB103 lacked the growth defect and the hygromycin B...

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