Article
Rewiring yeast sugar transporter preference through modifying a conserved protein motif.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014
Young Eric M, Tong Alice, Bui Hang, Spofford Caitlin, Alper Hal S
Abstract excerpt
Utilization of exogenous sugars found in lignocellulosic biomass hydrolysates, such as xylose, must be improved before yeast can serve as an efficient biofuel and biochemical production platform. In particular, the first step in this process, the molecular transport of xylose into the cell, can serve as a significant flux bottleneck and is highly inhibited by other sugars. Here we demonstrate that sugar transport...
Topics
- Amino Acid Motifs
- Biofuels
- Biological Transport
- Biomass
- Candida
- Cloning, Molecular
- Escherichia coli
- Fermentation
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Glucose
- Monosaccharide Transport Proteins
- Monosaccharides
- Mutation