Cellular Consequences of Diminished Protein O-Mannosyltransferase Activity in Baker's Yeast.

doi:10.3390/ijms18061226

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Article

Cellular Consequences of Diminished Protein O-Mannosyltransferase Activity in Baker's Yeast.

International journal of molecular sciences - 9 Jun 2017

Zatorska Ewa, Gal Lihi, Schmitt Jaro, Bausewein Daniela, Schuldiner Maya, Strahl Sabine

Abstract excerpt

O-Mannosylation is a type of protein glycosylation initiated in the endoplasmic reticulum (ER) by the protein O-mannosyltransferase (PMT) family. Despite the vital role of O-mannosylation, its molecular functions and regulation are not fully characterized. To further explore the cellular impact of protein O-mannosylation, we performed a genome-wide screen to identify Saccharomyces cerevisiae mutants with...

Topics

Cell Wall
Endoplasmic Reticulum
Enzyme Activation
Gene Expression
Glycosylation
Mannosyltransferases
Models, Molecular
Mutation
Saccharomyces cerevisiae
Substrate Specificity
Unfolded Protein Response

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Identifiers

PMID: 28598353
DOI: 10.3390/ijms18061226
PMCID: PMC5486049

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