Article
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study.
Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Mar 2010
Junyent M, Tucker K L, Shen J, Lee Y-C, Smith C E, Mattei J, Lai C-Q, Parnell L D, Ordovas J M
Abstract excerpt
BACKGROUND AND AIMS: Using a genetic predisposition score (GPS), integrating the additive associations of a set of single nucleotide polymorphisms (SNPs) with CHD, we examined the consequences of the joint presence of a high GPS and conventional risk factors (CRFs). METHODS AND RESULTS: We studied 11 SNPs at eight loci in 197 participants with prior CHD and 524 CHD-free subjects from the Boston Puerto Rican...
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