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Article

Possible contribution of DNase gamma to immunoglobulin V gene diversification.

Immunology letters - 30 Jun 2009

Okamoto Noriaki, Okamoto Mariko, Araki Shinsuke, Arakawa Hiroshi, Mizuta Ryushin, Kitamura Daisuke

Abstract excerpt

Somatic hypermutation (SHM) diversifies the rearranged immunoglobulin variable (V) region gene in B cells, contributing to affinity maturation of antibodies. It is believed that SHM is generated either by direct replication or by error-prone repair systems resolving V region DNA lesions caused directly or indirectly by cytidine deaminase AID. In accord with a part of these mechanisms, it was reported that SHM is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19501119
DOI: 10.1016/j.imlet.2009.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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