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Article

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.

The EMBO journal - 2 Nov 2005

Zan Hong, Shima Naoko, Xu Zhenming, Al-Qahtani Ahmed, Evinger Iii Albert J, Zhong Yuan, Schimenti John C, Casali Paolo

Abstract excerpt

Immunoglobulin (Ig) somatic hypermutation (SHM) critically underlies the generation of high-affinity antibodies. Mutations can be introduced by error-prone polymerases such as polymerase zeta (Rev3), a mispair extender, and polymerase eta, a mispair inserter with a preference for dA/dT, while repairing DNA lesions initiated by AID-mediated deamination of dC to yield dU:dG mismatches. The partial impairment of SHM...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16222339
DOI: 10.1038/sj.emboj.7600833
PMCID: PMC1276717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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