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Article

An evolutionary view of the mechanism for immune and genome diversity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2012

Kato Lucia, Stanlie Andre, Begum Nasim A, Kobayashi Maki, Aida Masatoshi, Honjo Tasuku

Abstract excerpt

An ortholog of activation-induced cytidine deaminase (AID) was, evolutionarily, the first enzyme to generate acquired immune diversity by catalyzing gene conversion and probably somatic hypermutation (SHM). AID began to mediate class switch recombination (CSR) only after the evolution of frogs. R...

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Source

Identifiers

PMID: 22492685
DOI: 10.4049/jimmunol.1102397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22492685-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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