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Article

Activation-induced cytidine deaminase links class switch recombination and somatic hypermutation.

Annals of the New York Academy of Sciences - 1 Apr 2003

Okazaki Ilmi, Yoshikawa Kiyotsugu, Kinoshita Kazou, Muramatsu Masamichi, Nagaoka Hitoshi, Honjo Tasaku

Abstract excerpt

Activation-induced cytidine deaminase (AID), a putative RNA-editing cytidine deaiminase that is expressed strictly in activated B cells, is indispensable in three apparently distinct genetic alterations of immunoglobulin genes-namely, class switch recombination, somatic hypermutation, and gene conversion. Recent findings led us to propose a common DNA cleaving mechanism, in which the transient secondary structure...

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Identifiers

PMID: 12727618
DOI: 10.1111/j.1749-6632.2003.tb06027.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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