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Article

Understanding the immunoglobulin locus specificity of hypermutation.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Batrak Vera, Blagodatski Artem, Buerstedde Jean-Marie

Abstract excerpt

The immunoglobulin (Ig) genes of B cells are diversified at high rate by point mutations whereas the non-Ig genes of B cells accumulate no or significantly fewer mutations. Ig hypermutations are critical for the affinity maturation of antibodies for most of jawed vertebrates and also contribute to the primary Ig diversity repertoire formation in some species. How the hypermutation activity is specifically...

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PMID: 21660702
DOI: 10.1007/978-1-61779-129-1_18

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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