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Article

Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder.

Genes, brain, and behavior - 1 Jul 2009

Lee B-T, Lee H-Y, Lee B-C, Pae C-U, Yoon B-J, Ryu S-G, Choi I-G, Lee M-S, Ham B-J

Abstract excerpt

Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major...

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Source

Identifiers

PMID: 19500158
DOI: 10.1111/j.1601-183X.2009.00500.x

Genes

TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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