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Article

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2005

Canli T, Congdon E, Gutknecht L, Constable R T, Lesch K P

Abstract excerpt

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

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Source

Identifiers

PMID: 16245070
DOI: 10.1007/s00702-005-0391-4

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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