Article
A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity.
Molecular psychiatry - 1 Sept 2005
Brown S M, Peet E, Manuck S B, Williamson D E, Dahl R E, Ferrell R E, Hariri A R
Abstract excerpt
Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Genetic variation in the human TPH2 gene (hTPH2) has been associated with altered in vitro enzyme activity as well as increased risk for mood disorders. Here, we provide the first in vivo evidence that a relatively frequent...
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