Article
ITPase-deficient mice show growth retardation and die before weaning.
Cell death and differentiation - 1 Oct 2009
Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi Y N, Tsuchimoto D, Nakabeppu Y
Abstract excerpt
Inosine triphosphate pyrophosphatase (ITPase), the enzyme that hydrolyzes ITP and other deaminated purine nucleoside triphosphates to the corresponding purine nucleoside monophosphate and pyrophosphate, is encoded by the Itpa gene. In this study, we established Itpa knockout (KO) mice and used them to show that ITPase is required for the normal organization of sarcomeres in the heart. Itpa(-/-) mice died about 2...
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