Article
Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2004
Warskulat Ulrich, Flögel Ulrich, Jacoby Christoph, Hartwig Hans-Georg, Thewissen Michael, Merx Marc W, Molojavyi Andrej, Heller-Stilb Birgit, Schrader Jürgen, Häussinger Dieter
Abstract excerpt
Taurine is the most abundant free amino acid in heart and skeletal muscle. In the present study, the effects of hereditary taurine deficiency on muscle function were examined in taurine transporter knockout (taut-/-) mice. These mice show an almost complete depletion of heart and skeletal muscle...
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