Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.

doi:10.1128/MCB.22.14.5212-5221.2002

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Article

Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.

Molecular and cellular biology - 1 Jul 2002

Haraguchi Misako, Tsujimoto Hiroaki, Fukushima Masakazu, Higuchi Itsuro, Kuribayashi Hideto, Utsumi Hideo, Nakayama Atsuo, Hashizume Yoshio, Hirato Junko, Yoshida Hiroki, Hara Hiromitsu, Hamano Shinjiro, Kawaguchi Hiroaki, Furukawa Tatsuhiko, Miyazono Kohei, Ishikawa Fuyuki, Toyoshima Hideo, Kaname Tadashi, Komatsu Masaharu, Chen Zhe-Sheng, Gotanda Takenari, Tachiwada Tokushi, Sumizawa Tomoyuki, Miyadera Kazutaka, Osame Mitsuhiro, Yoshida Hiroki, Noda Tetsuo, Yamada Yuji, Akiyama Shin-ichi

Abstract excerpt

Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels. TP deficiency is hypothesized to (i) increase levels of thymidine in plasma, (ii) lead to mitochondrial DNA alterations, and (iii) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). In order to elucidate the physiological roles of TP, we generated mice deficient in the TP gene. Although TP activity in the liver was...

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PMID: 12077348
DOI: 10.1128/MCB.22.14.5212-5221.2002
PMCID: PMC139774

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