Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.

doi:10.1128/MCB.22.14.5212-5221.2002

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Article

Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.

Molecular and cellular biology - 1 Jul 2002

Haraguchi Misako, Tsujimoto Hiroaki, Fukushima Masakazu, Higuchi Itsuro, Kuribayashi Hideto, Utsumi Hideo, Nakayama Atsuo, Hashizume Yoshio, Hirato Junko, Yoshida Hiroki, Hara Hiromitsu, Hamano Shinjiro, Kawaguchi Hiroaki, Furukawa Tatsuhiko, Miyazono Kohei, Ishikawa Fuyuki, Toyoshima Hideo, Kaname Tadashi, Komatsu Masaharu, Chen Zhe-Sheng, Gotanda Takenari, Tachiwada Tokushi, Sumizawa Tomoyuki, Miyadera Kazutaka, Osame Mitsuhiro, Yoshida Hiroki, Noda Tetsuo, Yamada Yuji, Akiyama Shin-ichi

Abstract excerpt

Thymidine phosphorylase (TP) regulates intracellular and plasma thymidine levels. TP deficiency is hypothesized to (i) increase levels of thymidine in plasma, (ii) lead to mitochondrial DNA alterations, and (iii) cause mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). In order to elu...

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PMID: 12077348
DOI: 10.1128/MCB.22.14.5212-5221.2002
PMCID: PMC139774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12077348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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