Article
Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.
Aging - 1 Aug 2010
Romero-Suarez Sandra, Shen Jinhua, Brotto Leticia, Hall Todd, Mo Chenglin, Valdivia Héctor H, Andresen Jon, Wacker Michael, Nosek Thomas M, Qu Cheng-Kui, Brotto Marco
Abstract excerpt
We have recently reported that a novel muscle-specific inositide phosphatase (MIP/MTMR14) plays a critical role in [Ca2+]i homeostasis through dephosphorylation of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,5) bisphosphate (PI(3,5)P2). Loss of function mutations in MIP have been identified in human centronuclear myopathy. We developed a MIP knockout (MIPKO) animal model and found that MIPKO mice were...
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