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Article

Analysis of human ITPase nucleobase specificity by site-directed mutagenesis.

Biochimie - 1 Sept 2013

Gall Amanda D, Gall Anthony, Moore Ashley C, Aune Martin K, Heid Steven, Mori Ayaka, Burgis Nicholas E

Abstract excerpt

Inosine triphosphate (ITP) pyrophosphohydrolase, or ITPase, is an intracellular enzyme that is responsible for the hydrolysis of the acidic anhydride bond between the alpha and beta phosphates in ITP, and other noncanonical nucleoside triphosphates, producing the corresponding nucleoside monophosphate and pyrophosphate. This activity protects the cell by preventing noncanonical nucleoside triphosphates from...

Topics

Adenine
Conserved Sequence
Escherichia coli
Humans
Mutagenesis, Site-Directed
Mutation
Nucleotides
Pyrophosphatases
Recombinant Proteins
Substrate Specificity
Inosine Triphosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23770441
DOI: 10.1016/j.biochi.2013.05.016

Genes

ITPA

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