Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.

Scientific reports - 20 Feb 2020

Chande Sampada, Caballero Daniel, Ho Bryan B, Fetene Jonathan, Serna Juan, Pesta Dominik, Nasiri Ali, Jurczak Michael, Chavkin Nicholas W, Hernando Nati, Giachelli Cecilia M, Wagner Carsten A, Zeiss Caroline, Shulman Gerald I, Bergwitz Clemens

Abstract excerpt

Low blood phosphate (Pi) reduces muscle function in hypophosphatemic disorders. Which Pi transporters are required and whether hormonal changes due to hypophosphatemia contribute to muscle function is unknown. To address these questions we generated a series of conditional knockout mice lacking one or both house-keeping Pi transporters Pit1 and Pit2 in skeletal muscle (sm), using the postnatally expressed human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hand Strength
Share to Muscle Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Fibers, Skeletal

Share to Necrosis

Share to Oxygen Consumption

Share to Phosphates

Share to Sodium-Phosphate Cotransporter Proteins, Type III

Share to Transcription Factor Pit-1

Source

Open in PubMed Open full text

Identifiers

PMID: 32080237
DOI: 10.1038/s41598-020-59430-4
PMCID: PMC7033257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.PMID 32080237Read ↗

The phosphate transporter PiT1 (Slc20a1) revealed as a new essential gene for mouse liver development.Semantic proximity Read ↗

Homozygous Loss-of-Function Variant in SLC20A1 Coding for Ubiquitous Phosphate Transporter PiT1 Is Associated With Multiple Developmental Abnormalities.Semantic proximity Read ↗

Mice with hypomorphic expression of the sodium-phosphate cotransporter PiT1/Slc20a1 have an unexpected normal bone mineralization.Semantic proximity Read ↗

Primary Brain Calcification Causal PiT2 Transport-Knockout Variants can Exert Dominant Negative Effects on Wild-Type PiT2 Transport Function in Mammalian Cells.Semantic proximity Read ↗

Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis.Semantic proximity Read ↗

A New Isoform of Human Myosin Phosphatase Targeting/Regulatory Subunit (MYPT2): cDNA Cloning, Tissue Expression, and Chromosomal MappingSemantic proximity Read ↗

Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction.Semantic proximity Read ↗

Metabolic regulation of skeletal cell fate and function in physiology and diseaseSemantic proximity Read ↗

PI(4,5)P <sub>2</sub> role in Transverse-tubule membrane formation and muscle functionSemantic proximity Read ↗

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging.Semantic proximity Read ↗

Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration.Semantic proximity Read ↗

Slc20a2 is critical for maintaining a physiologic inorganic phosphate level in cerebrospinal fluid.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.