Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.

Cells - 24 Jan 2022

Zamzami Mazin A

Abstract excerpt

Inosine triphosphate pyrophosphatase (ITPase) is an enzyme encoded by the ITPA gene and functions to prevent the incorporation of noncanonical purine nucleotides into DNA and RNA. Specifically, the ITPase catalyzed the hydrolysis of (deoxy) nucleoside triphosphates ((d) NTPs) into the corresponding nucleoside monophosphate with the concomitant release of pyrophosphate. Recently, thiopurine drug metabolites such...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inosine
Share to Mutation
Share to Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nucleosides

Share to Nucleotides

Share to Pyrophosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 35159194
DOI: 10.3390/cells11030384
PMCID: PMC8833965

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.PMID 35159194Read ↗

A disease spectrum for ITPA variation: advances in biochemical and clinical research.Semantic proximity Read ↗

Pharmacogenetic significance of inosine triphosphatase.Semantic proximity Read ↗

Analysis of human ITPase nucleobase specificity by site-directed mutagenesis.Semantic proximity Read ↗

Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase.Semantic proximity Read ↗

Inborn errors of purine metabolism: clinical update and therapiesSemantic proximity Read ↗

Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapySemantic proximity Read ↗

The ITPA c.94C>A and g.IVS2+21A>C sequence variants contribute to missplicing of the ITPA gene.Semantic proximity Read ↗

Purine nucleoside phosphorylase deficiency: a mutation update.Semantic proximity Read ↗

Crystal structure of human inosine triphosphatase. Substrate binding and implication of the inosine triphosphatase deficiency mutation P32T.Semantic proximity Read ↗

Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signatureSemantic proximity Read ↗

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPATSemantic proximity Read ↗

Purines and Pyrimidines: Metabolism, Function and Potential as Therapeutic Options in Neurodegenerative DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.