Article
Pharmacological and immunochemical characterization of alpha2* nicotinic acetylcholine receptors (nAChRs) in mouse brain.
Acta pharmacologica Sinica - 1 Jun 2009
Whiteaker Paul, Wilking Jennifer A, Brown Robert W B, Brennan Robert J, Collins Allan C, Lindstrom Jon M, Boulter Jim
Abstract excerpt
AIM: alpha2 nAChR subunit mRNA expression in mice is most intense in the olfactory bulbs and interpeduncular nucleus. We aimed to investigate the properties of alpha2* nAChRs in these mouse brain regions. METHODS: alpha2 nAChR subunit-null mutant mice were engineered. Pharmacological and immunoprecipitation studies were used to determine the composition of alpha2 subunit-containing (alpha2*) nAChRs in these two...
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