Article
A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.
Cancer cell - 14 Sept 2010
Post Sean M, Quintás-Cardama Alfonso, Pant Vinod, Iwakuma Tomoo, Hamir Amir, Jackson James G, Maccio Daniela R, Bond Gareth L, Johnson David G, Levine Arnold J, Lozano Guillermina
Abstract excerpt
MDM2, a negative regulator of p53, is elevated in many cancers that retain wild-type p53. A single nucleotide polymorphism (SNP) in the human MDM2 promoter increases the affinity of Sp1 resulting in elevated MDM2 levels. We generated mice carrying either the MDM2(SNP309T) or the MDM2(SNP309G) allele to address the impact of MDM2(SNP309G) on tumorigenesis. Mdm2(SNP309G/G) cells exhibit elevated Mdm2 levels,...
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