Article
Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649).
Oncotarget - 30 Sept 2014
Knappskog Stian, Gansmo Liv B, Dibirova Khadizha, Metspalu Andres, Cybulski Cezary, Peterlongo Paolo, Aaltonen Lauri, Vatten Lars, Romundstad Pål, Hveem Kristian, Devilee Peter, Evans Gareth D, Lin Dongxin, Van Camp Guy, Manolopoulos Vangelis G, Osorio Ana, Milani Lili, Ozcelik Tayfun, Zalloua Pierre, Mouzaya Francis, Bliznetz Elena, Balanovska Elena, Pocheshkova Elvira, Kučinskas Vaidutis, Atramentova Lubov, Nymadawa Pagbajabyn, Titov Konstantin, Lavryashina Maria, Yusupov Yuldash, Bogdanova Natalia, Koshel Sergey, Zamora Jorge, Wedge David C, Charlesworth Deborah, Dörk Thilo, Balanovsky Oleg, Lønning Per E
Abstract excerpt
The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and endometrial cancer. Assessing SNP285 and 309 genotypes across 25 different ethnic populations (>10.000 individuals), the incidence of SNP285C was 6-8% across European populations except for Finns...
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