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Article

Haplotype structure and selection of the MDM2 oncogene in humans.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Atwal Gurinder Singh, Bond Gareth L, Metsuyanim Sally, Papa Moshe, Friedman Eitan, Distelman-Menachem Tal, Ben Asher Edna, Lancet Doron, Ross David A, Sninsky John, White Tomas J, Levine Arnold J, Yarden Ronit

Abstract excerpt

The MDM2 protein is an ubiquitin ligase that plays a critical role in regulating the levels and activity of the p53 protein, which is a central tumor suppressor. A SNP in the human MDM2 gene (SNP309 T/G) occurs at frequencies dependent on demographic history and has been shown to have important d...

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Identifiers

PMID: 17360557
DOI: 10.1073/pnas.0610998104
PMCID: PMC1838634

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17360557-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Haplotype structure and selection of the MDM2 oncogene in humans.PMID 17360557Read ↗

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MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.Semantic proximity Read ↗

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.Semantic proximity Read ↗

Mdm2 Snp309 G allele displays high frequency and inverse correlation with somatic P53 mutations in hepatocellular carcinoma.Semantic proximity Read ↗

Prognostic impact of the MDM2SNP309 allele in leukemia and lymphoma.Semantic proximity Read ↗

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.Semantic proximity Read ↗

Identification of functional DNA variants in the constitutive promoter region of MDM2.Semantic proximity Read ↗

Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.Semantic proximity Read ↗

The MDM2 polymorphism SNP309 is associated with clinical characteristics and outcome in diffuse large B-cell lymphoma.Semantic proximity Read ↗

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