Article
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
Cell - 24 Nov 2004
Bond Gareth L, Hu Wenwei, Bond Elisabeth E, Robins Harlan, Lutzker Stuart G, Arva Nicoleta C, Bargonetti Jill, Bartel Frank, Taubert Helge, Wuerl Peter, Onel Kenan, Yip Linwah, Hwang Shih-Jen, Strong Louise C, Lozano Guillermina, Levine Arnold J
Abstract excerpt
The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonable to assume that naturally occurring polymorphic genetic variants in the p53 stress response pathway might determine an individual's susceptibility to cancer. A central node in the p53 pathway is the MDM2 protein, a direct negative regulator of p53. In this report, a single nucleotide polymorphism (SNP309) is found...
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