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Article

Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes.

Oncogene - 18 Jan 2018

Ortiz G J, Li Y, Post S M, Pant V, Xiong S, Larsson C A, El-Naggar A K, Johnson D G, Lozano G

Abstract excerpt

MDM2, an E3 ubiquitin ligase, is a potent inhibitor of the p53 tumor suppressor and is elevated in many human cancers that retain wild-type p53. MDM2 SNP309G is a functional polymorphism that results in elevated levels of MDM2 (due to enhanced SP1 binding to the MDM2 promoter) thus decreasing p53 activity. Mdm2SNP309G/G mice are more prone to spontaneous tumor formation than Mdm2SNP309T/T mice, providing direct...

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Identifiers

PMID: 28925402
DOI: 10.1038/onc.2017.344
PMCID: PMC5775049

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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