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Article

A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.

Carcinogenesis - 1 Nov 2009

Kulkarni Diptee A, Vazquez Alexei, Haffty Bruce G, Bandera Elisa V, Hu Wenwei, Sun Yvonne Y, Toppmeyer Deborah L, Levine Arnold J, Hirshfield Kim M

Abstract excerpt

Murine double minute 4 (MDM4) shares significant structural homology with murine double minute 2 (MDM2) and interacts and regulates transcriptional activity of the tumor suppressor p53. In tumors with wild-type p53, there is often overexpression of MDM2 or MDM4 leading to functional inactivation of p53. A single-nucleotide polymorphism (SNP) in the promoter of human MDM2 (SNP309) was shown to associate with...

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Source

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Identifiers

PMID: 19762336
DOI: 10.1093/carcin/bgp224
PMCID: PMC3895963

Genes

MDM4
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.PMID 19762336Read ↗

Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma.Semantic proximity Read ↗

[Correlation of polymorphism rs1563828 in MDM4 gene with breast cancer risk and onset age].Semantic proximity Read ↗

Association of MDM2 SNP309, age of onset, and gender in cutaneous melanoma.Semantic proximity Read ↗

Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status.Semantic proximity Read ↗

The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancer.Semantic proximity Read ↗

MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients.Semantic proximity Read ↗

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.Semantic proximity Read ↗

MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset.Semantic proximity Read ↗

The Role of MDM2 Amplification and Overexpression in Tumorigenesis.Semantic proximity Read ↗

Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.Semantic proximity Read ↗

MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population.Semantic proximity Read ↗

Association of breast cancer outcome with status of p53 and MDM2 SNP309.Semantic proximity Read ↗

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