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Article

Hyperaldosteronism, hypervolemia, and increased blood pressure in mice expressing defective APC.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2009

Bhandaru Madhuri, Kempe Daniela S, Rotte Anand, Rexhepaj Rexhep, Kuhl Dietmar, Lang Florian

Abstract excerpt

Adenomatous polyposis coli (APC) fosters degradation of beta-catenin, a multifunctional protein upregulating the serum- and glucocorticoid-inducible kinase (SGK1). SGK1 regulates a wide variety of renal transport processes. The present study explored the possibility that APC influences renal func...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19494170
DOI: 10.1152/ajpregu.00070.2009

Genes

APC
SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19494170-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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