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Article

Severe hyperkalemia is rescued by low-potassium diet in renal βENaC-deficient mice.

Pflugers Archiv : European journal of physiology - 1 Oct 2017

Boscardin Emilie, Perrier Romain, Sergi Chloé, Maillard Marc, Loffing Johannes, Loffing-Cueni Dominique, Koesters Robert, Rossier Bernard Claude, Hummler Edith

Abstract excerpt

In adulthood, an induced nephron-specific deficiency of αENaC (Scnn1a) resulted in pseudohypoaldosteronism type 1 (PHA-1) with sodium loss, hyperkalemia, and metabolic acidosis that is rescued through high-sodium/low-potassium (HNa+/LK+) diet. In the present study, we addressed whether renal βENaC expression is required for sodium and potassium balance or can be compensated by remaining (α and γ) ENaC subunits...

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PMID: 28567665
DOI: 10.1007/s00424-017-1990-2

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