Article
Progressive changes in adherens junction structure during intestinal adenoma formation in Apc mutant mice.
The Journal of biological chemistry - 19 Oct 2001
Carothers A M, Melstrom K A, Mueller J D, Weyant M J, Bertagnolli M M
Abstract excerpt
The C57BL/6J-Min/+ (Min/+) mouse bears a mutant Apc gene and therefore is an important in vivo model of intestinal tumorigenesis. Min/+ mice develop adenomas that exhibit loss of the wild-type Apc allele (Apc(Min/-)). Previously, we found that histologically normal enterocytes bearing a truncated Apc protein (Apc(Min/+)) migrated more slowly in vivo than enterocytes with either wild-type Apc (Apc(+/+)) or with...
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