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Article

Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.

The Journal of clinical investigation - 1 Apr 2003

Ni Xi-Ping, Pearce David, Butler Andrew A, Cone Roger D, Humphreys Michael H

Abstract excerpt

The gamma-melanocyte-stimulating hormone (gamma-MSH) is a natriuretic peptide derived from the N-terminal region of proopiomelanocortin (POMC). Evidence suggests that it may be part of the coordinated response to a low-sodium diet (LSD). We tested the effect of the HSD (8% NaCl) compared with LSD (0.07%) on mean arterial pressure (MAP) in mice with targeted disruption of the PC2 gene (PC2(-/-)), necessary for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sodium Chloride, Dietary

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Source

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Identifiers

PMID: 12697744
DOI: 10.1172/JCI16993
PMCID: PMC152936

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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