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Article

Processing of ENaC in mouse kidney: effects of aldosterone and a Liddle syndrome mutation.

American journal of physiology. Renal physiology - 1 Mar 2026

Frindt Gustavo, Yang Lei, Rohan Theresa, Palmer Lawrence G

Abstract excerpt

We investigated the interplay between the mineralocorticoid aldosterone and a mutation mimicking Liddle syndrome in the control of the processing of the epithelia Na+ channel (ENaC) in mouse kidneys. Rates of processing were assessed by the appearance of the cleaved form of the γENaC subunit. Cleaved γENaC increased with decreasing dietary Na intake and with administration of aldosterone. Measurements taken from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41500518
DOI: 10.1152/ajprenal.00398.2025
PMCID: PMC12947310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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