Article
Renal dopaminergic defect in C57Bl/6J mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Dec 2009
Escano Crisanto S, Armando Ines, Wang Xiaoyan, Asico Laureano D, Pascua Annabelle, Yang Yu, Wang Zheng, Lau Yuen-Sum, Jose Pedro A
Abstract excerpt
The C57Bl/6J mouse strain, the genetic background of many transgenic and gene knockout models, is salt sensitive and resistant to renal injury. We tested the hypothesis that renal dopaminergic function is defective in C57Bl/6J mice. On normal NaCl (0.8%, 1 wk) diet, anesthetized and conscious (telemetry) blood pressures were similar in C57Bl/6J and SJL/J mice. High NaCl (6%, 1 wk) increased blood pressure...
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