Article
Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction.
American journal of physiology. Gastrointestinal and liver physiology - 1 Dec 2001
Spicer Z, Clarke L L, Gawenis L R, Shull G E
Abstract excerpt
Upregulation of the colonic H(+)-K(+)- ATPase (cHKA) during hyperaldosteronism suggests that it functions in both K(+) conservation and electrogenic Na(+) absorption in the colon when Na(+)-conserving mechanisms are activated. To test this hypothesis, wild-type (cHKA(+/+)) and cHKA-deficient (cHKA(-/-)) mice were fed Na(+)-replete and Na(+)-restricted diets and their responses were analyzed. In both genotypes,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.