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Chronic lymphocytic leukemia and treatment resistance in cancer: The role of the p53 pathway

15 Dec 2008

Abstract excerpt

The importance of studying p53 pathway defects in CLL has been fostered by the demonstration of the fundamentally different clinical course of patients with 17p deletion, where the clinical course is, contrary to most patients with CLL, very poor. The demonstration of the resistance to chemotherapy and mutation of the remaining TP53 allele explains the clinical presentation of CLL with 17p deletion. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19098429
DOI: 10.4161/cc.7.24.7245

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