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Article

TP53 aberrations in chronic lymphocytic leukemia.

Advances in experimental medicine and biology - 1 Jan 2013

Trbusek Martin, Malcikova Jitka

Abstract excerpt

CLL patients harboring TP53 defects remain the most challenging group in terms of designing rational and effective therapy. Irrespective of the treatment employed-chemotherapy, chemoimmunotherapy, or pure biological drugs-median survival of these patients does not exceed 3-4 years. This adverse outcome is caused by a less effective response to therapeutics acting through DNA damage induction and relying on the...

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PMID: 24014294
DOI: 10.1007/978-1-4614-8051-8_5

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ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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