Article
TP53 aberrations in chronic lymphocytic leukemia.
Advances in experimental medicine and biology - 1 Jan 2013
Trbusek Martin, Malcikova Jitka
Abstract excerpt
CLL patients harboring TP53 defects remain the most challenging group in terms of designing rational and effective therapy. Irrespective of the treatment employed-chemotherapy, chemoimmunotherapy, or pure biological drugs-median survival of these patients does not exceed 3-4 years. This adverse o...
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