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Article

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.

American journal of medical genetics - 22 Jan 2002

Heijmans Bastiaan T, Slagboom P Eline, Gussekloo Jacobijn, Droog Simone, Lagaay A Margot, Kluft Cornelis, Knook Dick L, Westendorp Rudi G J

Abstract excerpt

The common apolipoprotein E (APOE) alleles epsilon2, epsilon3, and epsilon4 are associated with the risk of dementia and cardiovascular disease. Recently, two functional variants (- 219G/T and -491A/T) were identified in the promoter of the APOE gene that enable a further characterization of the role of the APOE locus in disease. We investigated the contribution of these APOE gene variants to dementia and...

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Source

Identifiers

PMID: 11807900
DOI: 10.1002/ajmg.10142

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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