Article
Steric gate variants of UmuC confer UV hypersensitivity on Escherichia coli.
Journal of bacteriology - 1 Aug 2009
Shurtleff Brenna W, Ollivierre Jaylene N, Tehrani Mohammad, Walker Graham C, Beuning Penny J
Abstract excerpt
Y family DNA polymerases are specialized for replication of damaged DNA and represent a major contribution to cellular resistance to DNA lesions. Although the Y family polymerase active sites have fewer contacts with their DNA substrates than replicative DNA polymerases, Y family polymerases appear to exhibit specificity for certain lesions. Thus, mutation of the steric gate residue of Escherichia coli DinB...
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