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Article

A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates.

Nature - 12 Jan 2006

Jarosz Daniel F, Godoy Veronica G, Delaney James C, Essigmann John M, Walker Graham C

Abstract excerpt

Translesion synthesis (TLS) by Y-family DNA polymerases is a chief mechanism of DNA damage tolerance. Such TLS can be accurate or error-prone, as it is for bypass of a cyclobutane pyrimidine dimer by DNA polymerase eta (XP-V or Rad30) or bypass of a (6-4) TT photoproduct by DNA polymerase V (UmuD'2C), respectively. Although DinB is the only Y-family DNA polymerase conserved among all domains of life, the...

Topics

Amino Acids
Animals
Base Pair Mismatch
Catalysis
Conserved Sequence
DNA
DNA Adducts
DNA Damage
DNA Replication
DNA-Directed DNA Polymerase
Deoxyguanosine
Escherichia coli Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kinetics

Mutagens

Mutation

Substrate Specificity

Templates, Genetic

Source

Identifiers

PMID: 16407906
DOI: 10.1038/nature04318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates.PMID 16407906Read ↗

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